Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12540/96
Title: Evolutionary study of Yersinia genomes deciphers emergence of human pathogenic species
Authors: Tan, Shi Y. 
Tan, Irene K. P. 
Tan, Mui F. 
Dutta, Avirup 
Choo, Siew W. 
Issue Date: 2016
Publisher: Springer Nature
Source: Tan, S. Y., Tan, I. K. P., Tan, M. F., Dutta, A., & Choo, S. W. (2016). Evolutionary study of Yersinia genomes deciphers emergence of human pathogenic species. Scientific Reports, 6, 36116.
Journal: Scientific Reports 
Abstract: On record, there are 17 species in the Yersinia genus, of which three are known to be pathogenic to human. While the chromosomal and pYV (or pCD1) plasmid-borne virulence genes as well as pathogenesis of these three species are well studied, their genomic evolution is poorly understood. Our study aims to predict the key evolutionary events that led to the emergence of pathogenic Yersinia species by analyzing gene gain-and-loss, virulence genes, and “Clustered regularly-interspaced short palindromic repeats”. Our results suggest that the most recent ancestor shared by the human pathogenic Yersinia was most probably an environmental species that had adapted to the human body. This might have led to ecological specialization that diverged Yersinia into ecotypes and distinct lineages based on differential gene gain-and-loss in different niches. Our data also suggest that Y. pseudotuberculosis group might be the donor of the ail virulence gene to Y. enterocolitica. Hence, we postulate that evolution of human pathogenic Yersinia might not be totally in parallel, but instead, there were lateral gene transfer events. Furthermore, the presence of virulence genes seems to be important for the positive selection of virulence plasmid. Our studies provide better insights into the evolutionary biology of these bacteria.
URI: https://hdl.handle.net/20.500.12540/96
DOI: 10.1038/srep36116
Appears in Collections:Scholarly Publications

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