Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12540/55
Title: An Arabidopsis clathrin assembly protein with a predicted role in plant defense can function as an adenylate cyclase
Authors: Chatukuta, Patience 
Dikobe, Tshegofatso B. 
Kawadza, David T. 
Sehlabane, Katlego S. 
Takundwa, Mutsa M. 
Wong, Aloysius 
Gehring, Chris 
Ruzvidzo, Oziniel 
Issue Date: 2018
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
Source: Chatukuta, P., Dikobe, T. B., Kawadza, D. T., Sehlabane, K. S., Takundwa, M. M., Wong, A., ... & Ruzvidzo, O. (2018). An Arabidopsis clathrin assembly protein with a predicted role in plant defense can function as an adenylate cyclase. Biomolecules, 8(2), 15.
Journal: Biomolecules 
Abstract: Adenylate cyclases (ACs), much like guanylate cyclases (GCs), are increasingly recognized as essential parts of many plant processes including biotic and abiotic stress responses. In order to identify novel ACs, we have applied a search motif derived from experimentally tested GCs and identified a number of Arabidopsis thaliana candidates including a clathrin assembly protein (AT1G68110; AtClAP). AtClAP contains a catalytic centre that can complement the AC-deficient mutant cyaA in E. coli, and a recombinant AtClAP fragment (AtClAP261–379) can produce cyclic adenosine 3′,5′ monophosphate (cAMP) from adenosine triphosphate (ATP) in vitro. Furthermore, an integrated analysis of gene expression and expression correlation implicate cAMP in pathogen defense and in actin cytoskeletal remodeling during endocytic internalization.
URI: https://hdl.handle.net/20.500.12540/55
DOI: 10.3390/biom8020015
Appears in Collections:Scholarly Publications

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