Please use this identifier to cite or link to this item:
DC FieldValueLanguage
dc.contributor.authorWang, Yuxuanen_US
dc.contributor.authorJiang, Yinyinen_US
dc.contributor.authorDeng, Yuxinen_US
dc.contributor.authorYi, Chenen_US
dc.contributor.authorWang, Yangcanen_US
dc.contributor.authorDing, Mengnanen_US
dc.contributor.authorLiu, Jieen_US
dc.contributor.authorJin, Xuanjingen_US
dc.contributor.authorShen, Lishanen_US
dc.contributor.authorHe, Yueen_US
dc.contributor.authorWu, Xinyunen_US
dc.contributor.authorChen, Xuefeien_US
dc.contributor.authorSun, Changyien_US
dc.contributor.authorZheng, Minen_US
dc.contributor.authorZhang, Ruijiaen_US
dc.contributor.authorYe, Hailven_US
dc.contributor.authorAn, Huitingen_US
dc.contributor.authorWong, Aloysiusen_US
dc.identifier.citationWang, Y., Jiang, Y., Deng, Y., Yi, C., Wang, Y., Ding, M., ... & Wong, A. (2020). Probiotic supplements: Hope or hype?. Frontiers in Microbiology, 11, 160.en_US
dc.description.abstractProbiotic bacteria have been associated with various health benefits and included in overwhelming number of foods. Today, probiotic supplements are consumed with increasing regularity and record a rapidly growing economic value. With billions of heterogeneous populations of probiotics per serving, probiotic supplements contain the largest quantity of probiotics across all functional foods. They often carry antibiotic-resistant determinants that can be transferred to and accumulate in resident bacteria of the gastrointestinal tract and risk their acquisitions by opportunistic pathogens. While the health benefits of probiotics have been widely publicized, this health risk, however, is underrepresented in both scientific studies and public awareness. On the other hand, the human gut presents conditions that are unfavorable for bacteria, including probiotics. It remains uncertain if probiotics from supplements can tolerate acids and bile salts that may undermine their effectiveness in conferring health benefits. Here, we put into perspective the perceived health benefits and the long-term safety of consuming probiotic supplements, specifically bringing intolerance to acids and bile salts, and the long-standing issue of antibiotic-resistant gene transfer into sharp focus. We report that probiotics from supplements examined in this study have poor tolerance to acids and bile salts while also displaying resistance to multiple antibiotics. They could also adapt and gain resistance to streptomycin in vitro. In an environment where consuming supplements is considered a norm, our results and that of others will put in perspective the persisting concerns surrounding probiotic supplements so that the current hype does not overpower the hope.en_US
dc.format.extent9 pagesen_US
dc.publisherFrontiers Media S.A.en_US
dc.relation.ispartofFrontiers in Microbiologyen_US
dc.subject.lcshAntibiotic Resistanceen_US
dc.subject.lcshHealth/Dietary Supplementsen_US
dc.subject.lcshHorizontal Gene Transferen_US
dc.subject.lcshLactic Acid Bacteriaen_US
dc.titleProbiotic supplements: Hope or hype?en_US
dc.rights.licenseAttribution-NonCommercial 4.0 International (CC BY-NC 4.0)en_US
dc.subject.keywordsAdaptive Evolutionen_US
Appears in Collections:Scholarly Publications
Files in This Item:
File Description SizeFormat 
wku_schlrs_publcn_000022.pdf1.61 MBAdobe PDFThumbnail
Show simple item record

Page view(s)

checked on Sep 27, 2020


checked on Sep 27, 2020

Google ScholarTM



This item is licensed under a Creative Commons License Creative Commons