Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12540/104
Title: Genomic reconnaissance of multiple, clinically isolates of emerging human pathogen Mycobacterium abscessus reveals high evolutionary potential
Authors: Choo, Siew W. 
Wee, Wei Y. 
Ngeow, Yun F. 
Mitchell, Wayne 
Tan, Joon L. 
Wong, Guat J. 
Zhao, Yongbing 
Xiao, Jingfa 
Issue Date: 2014
Publisher: Springer Nature
Source: Choo, S. W., Wee, W. Y., Ngeow, Y. F., Mitchell, W., Tan, J. L., Wong, G. J., ... & Xiao, J. (2014). Genomic reconnaissance of clinical isolates of emerging human pathogen Mycobacterium abscessus reveals high evolutionary potential. Scientific Reports, 4, 4061.
Journal: Scientific Reports 
Abstract: Mycobacterium abscessus (Ma) is an emerging human pathogen that causes both soft tissue infections and systemic disease. We present the first comparative whole-genome study of Ma strains isolated from patients of wide geographical origin. We found a high proportion of accessory strain-specific genes indicating an open, non-conservative pan-genome structure and clear evidence of rapid phage-mediated evolution. Although we found fewer virulence factors in Ma compared to M. tuberculosis, our data indicated that Ma evolves rapidly and therefore should be monitored closely for the acquisition of more pathogenic traits. This comparative study provides a better understanding of Ma and forms the basis for future functional work on this important pathogen.
URI: https://hdl.handle.net/20.500.12540/104
DOI: 10.1038/srep04061
Appears in Collections:Scholarly Publications

Files in This Item:
File Description SizeFormat 
wku_schlrs_publcn_000077.pdf1.85 MBAdobe PDFThumbnail
View/Open
Show full item record

Page view(s)

727
checked on Sep 19, 2021

Download(s)

156
checked on Sep 19, 2021

Google ScholarTM

Check

Altmetric


This item is licensed under a Creative Commons License Creative Commons